Modeling the pharmacodynamics of passive membrane permeability
نویسندگان
چکیده
منابع مشابه
Modeling the pharmacodynamics of passive membrane permeability
Small molecule permeability through cellular membranes is critical to a better understanding of pharmacodynamics and the drug discovery endeavor. Such permeability may be estimated as a function of the free energy change of barrier crossing by invoking the barrier domain model, which posits that permeation is limited by passage through a single "barrier domain" and assumes diffusivity differenc...
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ژورنال
عنوان ژورنال: Journal of Computer-Aided Molecular Design
سال: 2011
ISSN: 0920-654X,1573-4951
DOI: 10.1007/s10822-011-9480-7